In Metz, on the occasion of the marriage of Austrasian King Sigebert the First to the Visigothic Princess Brunehilde, Venantius wrote a wedding poem modeled on the Ancient Epithalamium, which gave him access to the secular and spiritual upper layer of the Merovingian Frankish Empire. He wrote about a boat trip on the Moselle between Metz and Andernach, two residential cities of the Kingdom of Austrasia. The poem is entitled De Navigio Suo (about this yourney); he accompanied the young King Childebert the Second on his Moselle joutney. 

Venantius built a personal relationship with Radegonde, the widow of King Chlotarius the First, and her foster daugther Agnes, who had both retired to a monastery. Venantius became priest and chaplain of the monastery. Commisioned by Radegonda, Venantius, who in the meantime enjoyed an excellent reputation as a Latin poet, undertoke several trips. He was also active in literature for Radegonda. Bishop Gregory of Tours, became one of his patrons. Towards the end of his life, Venantius Fortunatus became Bishop of Poitiers.